Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data.
Nick MarcksAlberto AimoJames L JanuzziGiuseppe VergaroAldo ClericoRoberto LatiniJennifer MeessenInder S AnandJay N CohnJørgen GravningThor UelandAntoni Bayes-GenisJosep LupónRudolf A de BoerAkiomi YoshihisaYasuchika TakeishiMichael EgstrupIda GustafssonHanna K GagginKai M EggersKurt HuberIoannis TentzerisAndrea RipoliClaudio PassinoSandra Sanders-van WijkMichele EmdinHans-Peter Brunner-La RoccaPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
The present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF. Categories of BMI are only predictive of poor outcome in patients aged > 75 years or with at least one co-morbidity (bottom), but not in those aged < 75 years without co-morbidities (top). The prognostic effect largely disappears in multivariable analyses even for the former group. These findings question the protective effect of obesity in chronic heart failure (HF).
Keyphrases
- insulin resistance
- weight loss
- metabolic syndrome
- weight gain
- heart failure
- type diabetes
- ejection fraction
- high fat diet induced
- end stage renal disease
- newly diagnosed
- acute heart failure
- body mass index
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- left ventricular
- adipose tissue
- electronic health record
- atrial fibrillation
- skeletal muscle
- physical activity
- patient reported outcomes