Normoxic re-oxygenation ameliorates end-organ injury after cardiopulmonary bypass.
Yun-Wen PengTerry MajorAzmath MohammedKristopher B DeatrickJohn R CharpiePublished in: Journal of cardiothoracic surgery (2020)
Normoxic reperfusion ameliorates cardiac, renal and neural injury compared with hyperoxic reperfusion in an in vivo animal model of CPB and cardioplegic arrest. This protective effect of normoxic reperfusion may be due to a reduction in signaling pathways for OS, inflammation, and apoptosis.
Keyphrases
- cerebral ischemia
- acute myocardial infarction
- oxidative stress
- acute ischemic stroke
- subarachnoid hemorrhage
- signaling pathway
- mouse model
- blood brain barrier
- left ventricular
- brain injury
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- percutaneous coronary intervention
- cell cycle
- coronary artery disease
- acute coronary syndrome