Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells.
Kalishwaralal KalimuthuBat-Chen LubinAndrii BazylevichGary GellermanOfer ShpilbergGalia LuboshitsMichael A FirerPublished in: Journal of nanobiotechnology (2018)
Peptide-drug-conjugates hold potential for improving the target efficacy of chemotherapeutic drugs, however their short half-lives may limit their application. This hurdle can be overcome by easily conjugating them to gold nanoparticles. This conjugation also opens up the possibility of developing slow release formulations of targeted drug delivery systems containing PDCs.