β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis.
Wei PanPengfei JiangJinxiu ZhaoHongli ShiPeng ZhangXiaoying YangJoanna BiazikMinmin HuHui HuaXing GeXu-Feng HuangYinghua YuPublished in: Journal of translational medicine (2021)
This study revealed that L. edodes β-glucan prevents cognitive impairments induced by the HF diet, which may occur via colon-brain axis improvement. The finding suggested that dietary L. edodes β-glucan supplementation may be an effective nutritional strategy to prevent obesity-associated cognitive decline.
Keyphrases
- high fat diet induced
- cognitive decline
- insulin resistance
- mild cognitive impairment
- resting state
- white matter
- weight loss
- metabolic syndrome
- type diabetes
- cell wall
- functional connectivity
- physical activity
- cerebral ischemia
- mouse model
- adipose tissue
- single cell
- heart failure
- weight gain
- skeletal muscle
- body mass index
- blood brain barrier