The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

María-Natalia LisaTristan WagnerMatthieu AlexandreNathalie BariloneBertrand RaynalPedro M AlzariMarco Bellinzoni

Published in: The FEBS journal (2017)

Atomic coordinates and structure factors for the catalytic domain of M. tuberculosis PknI are in the Protein Data Bank under the accession codes 5M06 (wild-type PknI + ADP), 5M07 (PknI_C20A), 5M08 (PknI_C20A_R136A) and 5M09 (PknI_C20A_R136N).

Keyphrases

mycobacterium tuberculosis
wild type
pulmonary tuberculosis
electronic health record
big data
machine learning
molecular dynamics simulations
human immunodeficiency virus
protein protein
deep learning
hiv infected
amino acid
antiretroviral therapy
drug induced