Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer.
Sherene LoiRoberto SalgadoSylvia AdamsGiancarlo PruneriPrudence A FrancisMagali Lacroix-TrikiHeikki JoensuuMaria Vittoria DieciSunil S BadveSandra DemariaRobert C GrayElisabetta MunzoneDamien DrubayJerome LemonnierChristos SotiriouPirkko Liisa Kellokumpu-LehtinenAndrea VingianiKathryn GrayFabrice AndreCarsten DenkertMartine PiccartElvire RoblinStefan MichielsPublished in: NPJ breast cancer (2022)
The importance of integrating biomarkers into the TNM staging has been emphasized in the 8 th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8 th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.
Keyphrases
- lymph node
- early stage
- pet ct
- papillary thyroid
- end stage renal disease
- ejection fraction
- squamous cell
- newly diagnosed
- chronic kidney disease
- sentinel lymph node
- prognostic factors
- peritoneal dialysis
- squamous cell carcinoma
- young adults
- childhood cancer
- radiation therapy
- study protocol
- neoadjuvant chemotherapy
- case control
- rectal cancer