Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors.
Neil T ConlonJeffrey J KooijmanSuzanne J C van GerwenWinfried R MulderGuido J R ZamanIrmina DialaLisa D EliAlshad S LalaniJohn CrownDenis M CollinsPublished in: British journal of cancer (2021)
Neratinib was the most effective HER2-targeted TKI against HER2-amplified, -mutant, and EGFR-mutant cell lines. This analysis revealed novel resistance mechanisms that may be exploited using combinatorial strategies.
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