In silico, in vitro and in vivo metabolite identification of brexpiprazole using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Disha ThakkarAbhijeet S KatePublished in: Rapid communications in mass spectrometry : RCM (2019)
All the 16 metabolites were identified and characterized using UHPLC/QTOF-MS/MS. The study revealed that brexpiprazole is metabolized via hydroxylation, glucuronidation, S-oxidation, N-oxidation, dioxidation, oxidative deamination, N-dealkylation, etc.
Keyphrases
- ms ms
- ultra high performance liquid chromatography
- tandem mass spectrometry
- major depressive disorder
- simultaneous determination
- liquid chromatography
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- high resolution mass spectrometry
- hydrogen peroxide
- gas chromatography
- mass spectrometry
- high resolution
- solid phase extraction
- bipolar disorder
- nitric oxide
- electron transfer