Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity.

Slava BergerHuy PhoThomaz Fleury-CuradoShannon Bevans-FontiHaris YounasMi-Kyung ShinJonathan C JunFrederick Anokye-DansoRexford S AhimaLynn W EnquistDavid MendelowitzAlan R SchwartzVsevolod Y Polotsky

Published in: American journal of respiratory and critical care medicine (2020)

In mice with DIO, intranasal leptin bypassed leptin resistance and significantly attenuated sleep-disordered breathing independently of body weight.

Keyphrases

high fat diet induced
body weight
insulin resistance
metabolic syndrome
type diabetes
weight loss
weight gain
skeletal muscle
adipose tissue