Riding up the escaLEC-TOR for valvular health.
Zoltan AranyPublished in: The Journal of cell biology (2023)
Endothelial-lined valves assure unidirectional flow in the lymphatic system. In this issue, Saygili Demir et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202207049) demonstrate how continuous repair of these valves occur, beginning with mTOR-activated cell replication in valve sinuses, and followed by cell migration to cover the valve surface.
Keyphrases
- aortic valve
- cell migration
- single cell
- mitral valve
- aortic valve replacement
- cell therapy
- transcatheter aortic valve replacement
- aortic stenosis
- healthcare
- transcatheter aortic valve implantation
- public health
- cell proliferation
- endothelial cells
- lymph node
- risk assessment
- atrial fibrillation
- coronary artery disease
- heart failure
- health promotion
- mesenchymal stem cells