Studying the Utility of Using Genetics to Predict Smoking-Related Outcomes in a Population-Based Study and a Selected Cohort.
Michael J BrayLi-Shiun ChenLouis FoxYinjiao MaRichard A GruczaSarah M HartzRobert C CulverhouseNancy L SacconeDana B HancockEric O JohnsonJames D McKayTimothy B BakerLaura J BierutPublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
This study shows that including both genetic ancestry and PRSs in a single model increases the ability to predict smoking behaviors compared with the model including only demographic characteristics. This finding is observed for every smoking-related outcome. Even though adding genetics is more predictive, the demographics alone confer substantial and meaningful predictive power. However, with increasing work in PRSs, the predictive ability will continue to improve.