A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.
Kexin ChenSilan ShenYiding ChenMingshan JiangKehan HuYuheng ZouLili LiZhen ZengChunxiang MaYuan DangHu ZhangPublished in: Scientific data (2022)
An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic analyses of intestinal tissues from chronic colitis mice following capsaicin administration and transcriptomic analyses of dHL-60 cells after capsaicin stimulation. Collectively, these multiomic analyses identified proteins and genes that may be involved in disease flares, thereby providing new insights for future research.
Keyphrases
- rna seq
- single cell
- signaling pathway
- induced apoptosis
- ulcerative colitis
- gene expression
- oxidative stress
- type diabetes
- genome wide
- physical activity
- cell cycle arrest
- endothelial cells
- epithelial mesenchymal transition
- pi k akt
- high glucose
- cell proliferation
- endoplasmic reticulum stress
- skeletal muscle
- human health
- depressive symptoms
- transcription factor
- wild type