Combined histological and DNA methylome profiling approaches may provide insights into the pathophysiology of ovarian endometriomas.
Norihiro SuginoYoshiaki OtaIkuko OtaYumiko MiharaHitomi TakasakiShun SatoIsao TamuraYuichiro ShirafutaMasahiro ShinagawaTaishi FujimuraAmon ShiroshitaToshihide YonedaMai Kawamoto-JozakiFuka MatsuiToshiaki TaketaniNorihiro SuginoPublished in: Reproductive medicine and biology (2023)
The present results support the invagination theory. Ovarian endometriomas consist of invaginated ovarian surface epithelium with celomic metaplasia and endometrium implants on the peritoneum.