An Alternatively Spliced p62 Isoform Confers Resistance to Chemotherapy in Breast Cancer.

Qianying Guo Hao Wang Jiahao Duan Wenwu Luo Rongrong Zhao Yuting Shen Bijun Wang Siqi Tao Yi Sun Qian Ye Xiaomin Bi Hui Yuan Qiang Wu Peter E Lobie Tao Zhu Sheng Tan Xing Huang Zheng-Sheng Wu

Published in: Cancer research (2022)

Resistance to NAC in breast cancer is driven by a novel p62 mRNA isoform that escapes miRNA-mediated repression and leads to increased p62 protein expression.

Keyphrases

transcription factor
locally advanced
squamous cell carcinoma