Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells.

Xiaowu BaiChi Chun WongYasi PanHuarong ChenWeixin LiuJianning ZhaiWei KangYu ShiMasami YamamotoTetsuya TsukamotoSachiyo NomuraPhilip ChiuChi Chun WongEnders Kwok-Wai Ng

Published in: Journal for immunotherapy of cancer (2022)

YTHDF1 is overexpressed in GC and promotes GC by inducing cell proliferation and repression of DCs-mediated antitumor immune response. YTHDF1 is a promising therapeutic target for GC treatment.

Keyphrases

dendritic cells
immune response
cell proliferation
gas chromatography
regulatory t cells
cell cycle
combination therapy
high resolution