Prolonged Versus Intermittent Infusion of β-Lactam Antibiotics: A Systematic Review and Meta-Regression of Bacterial Killing in Preclinical Infection Models.

Sofie A M Dhaese Aaron J Heffernan David Liu Mohd Hafiz Abdul-AzizVeronique StoveVincent H TamJeffrey LipmanJason A RobertsJan J De Waele

Published in: Clinical pharmacokinetics (2021)

Intermittent and prolonged infusions of β-lactam antibiotics require different PK/PD targets to obtain the same level of bacterial cell kill. The additional effect of a prolonged infusion for enhancing bacterial killing could not be demonstrated.

Keyphrases

low dose
cell therapy
high intensity
single cell
stem cells