Palladium-Catalyzed Cross Haloalkynylation of Haloalkynes.

Herein, we have developed a robust Pd-catalyzed haloalkynylation of haloalkynes for the synthesis of dihaloalkenyne derivatives. This cross-haloalkynylation reaction proceeds in a highly chemo- and regioselective manner under mild conditions in the presence of two slightly structurally different haloalkynes and shows strong functional group tolerance under ligand- and base-free conditions.