Variables associated with nonresponders to high-frequency (10 kHz) spinal cord stimulation.
Vinicius Tieppo FrancioJohn AlmLogan LeavittDaniel MokB Victor YoonNiaman NazirChristopher LamUsman LatifTimothy SowderEdward BraunAndrew SackTalal KhanDawood SayedPublished in: Pain practice : the official journal of World Institute of Pain (2023)
Our study is the first in the neuromodulation literature to raise awareness to the association of high levels of kinesiophobia preoperatively in nonresponders to 10 kHz SCS therapy. We also found statistically significant differences with greater pain intensity, higher self-perceived disability, and clinically relevant pain catastrophizing at baseline in the nonresponders relative to responders. It may be appropriate to screen for these factors preoperatively to identify patients who are less likely to respond to SCS. If these modifiable risk factors are present, it might be prudent to consider a pre-rehabilitation program with pain neuroscience education to address these factors prior to SCS therapy, to enhance successful outcomes in neuromodulation.
Keyphrases
- high frequency
- chronic pain
- transcranial magnetic stimulation
- neuropathic pain
- spinal cord
- pain management
- risk factors
- end stage renal disease
- healthcare
- chronic kidney disease
- spinal cord injury
- newly diagnosed
- ejection fraction
- systematic review
- quality improvement
- mental health
- physical activity
- prognostic factors
- high throughput
- type diabetes
- adipose tissue
- mesenchymal stem cells
- metabolic syndrome
- patient reported outcomes
- postoperative pain
- single cell
- skeletal muscle
- smoking cessation