ST88 ceftazidime-resistant Stenotrophomonas maltophilia is present in the saliva and gingival crevicular fluid of patients with periodontitis and AIDS from São Paulo State, Brazil.
Felipe Pinheiro VilelaAmanda Akemi KakumotoCarolina Nogueira GomesTábata Larissa Santos PólvoraAtila Vinícius Vitor NobreAlan Grupioni LourençoAna Carolina Fragoso MottaJuliana Pfrimer FalcãoPublished in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2024)
Stenotrophomonas maltophilia (S. maltophilia) is an intrinsically drug-resistant and biofilm-forming bacteria causing infections in immunocompromised humans. This study reports the isolation of five S. maltophilia strains from saliva and gingival crevicular fluid (GCF) of AIDS patients with periodontitis in São Paulo, Brazil, showing resistance to ceftazidime, strong biofilm formation capacity and a close genetic relationship. The presence of S. maltophilia strains in saliva and CGF of patients with AIDS and periodontitis is a concern for the presence and persistence of intrinsically resistant bacteria in the oral environment, enhancing the risk for the development of severe infections in immunocompromised patients.
Keyphrases
- drug resistant
- biofilm formation
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- candida albicans
- multidrug resistant
- antiretroviral therapy
- acinetobacter baumannii
- end stage renal disease
- ejection fraction
- gram negative
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- early onset
- patient reported outcomes
- intensive care unit
- electronic health record
- dna methylation
- adverse drug
- extracorporeal membrane oxygenation