Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation.

Chih-Chung LinWei-Ning Lin Rou-Ling ChoChien-Chung YangYi-Cheng YehLi-Der HsiaoHui-Ching TsengChuen-Mao Yang

Published in: Journal of clinical medicine (2020)

MVS-induced HO-1 is, at least in part, mediated through a p47phox/Nox2/ROS-dependent activation of c-Src/PDGFRα/PI3K/Akt-regulated Nrf2/ARE axis and suppresses the TNF-α-mediated inflammatory responses in HPAEpiCs.

Keyphrases

pi k akt
signaling pathway
oxidative stress
cell cycle arrest
cell proliferation
reactive oxygen species
diabetic rats
high glucose
rheumatoid arthritis
cell death
dna damage
tyrosine kinase
transcription factor
endothelial cells
stress induced