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Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity.

Wai Tuck SohLorenz AglasGeoffrey A MuellerStefanie GillesRichard WeissSandra ScheiblhoferSara HuberTamara ScheidtPeter M ThompsonPeter BrizaRobert E LondonClaudia Traidl-HoffmanChiara CabreleKatharina HäussermannFatima Ferreira
Published in: Allergy (2019)
Bet v 1 can serve as a transporter of pollen-derived, bioactive compounds. When carried to the endolysosome, such compounds can modulate the proteolytic activity, including its processing by cysteine cathepsins. We unveil a paradigm shift from an allergen-centered view to a more systemic view that includes the host endolysosomal enzymes.
Keyphrases
  • allergic rhinitis