Brain-derived neurotrophic factor Val66Met and neuropsychological functioning after early childhood traumatic brain injury.

Amery Treble-BarnaShari L WadeValentina PilipenkoLisa J MartinKeith Owen YeatesH Gerry TaylorBrad G Kurowski

Published in: Journal of the International Neuropsychological Society : JINS (2022)

The results suggest a differential effect of the BDNF Val66Met polymorphism on verbal fluency, and possibly fluid reasoning and immediate and delayed verbal memory, in children with early TBI relative to OI. The Met allele-associated with reduced activity-dependent secretion of BDNF-may confer risk for poorer neuropsychological functioning in children with TBI.

Keyphrases

traumatic brain injury
working memory
tyrosine kinase
young adults
mild cognitive impairment
severe traumatic brain injury