Endothelin A receptor blocker and calcimimetic in the adenine rat model of chronic renal insufficiency.

Suvi TörmänenIlkka PörstiPäivi LakkistoIlkka TikkanenOnni NiemeläTimo PaavonenJukka MustonenArttu Eräranta

Published in: BMC nephrology (2017)

In adenine-induced interstitial nephritis, sitaxentan improved renal function and tubular atrophy. Sitaxentan and cinacalcet reduced kidney renin mRNA by 40%, while their combination alleviated tubulointerstitial damage and urinary calcium loss, and increased kidney tissue ACE2 mRNA.

Keyphrases

angiotensin converting enzyme
high glucose
binding protein
angiotensin ii
diabetic rats
oxidative stress
endothelial cells
drug induced