Free cortisol and free 21-deoxycortisol in the clinical evaluation of congenital adrenal hyperplasia.
Bas P H AdriaansenAgustini UtariAndré J OlthaarRob C B M van der SteenKarijn J Pijnenburg-KleizenLizanne BerkenboschPaul N SpanFred C G J SweepHedi L Claahsen-van der GrintenAntonius E van HerwaardenPublished in: The Journal of clinical endocrinology and metabolism (2024)
Free cortisol concentrations in classic CAH patients were similar to those in controls and NCCAH patients, indicating comparable cortisol availability. Additionally, 21OHD patients produce high concentrations of 21DF, possibly explaining the low occurrence of symptoms in some classic 21OHD patients. Free cortisol and 21DF levels should be considered in evaluating adrenal insufficiency in patients with CAH.