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Copper-Catalyzed Tandem Aerobic Oxidative Cyclization for the Synthesis of Polysubstituted Quinolines via C(sp3)/C(sp2)-H Bond Functionalization.

Xiaobo PangMingzhong WuJixiang NiFuming ZhangJingfeng LanBao-Hua ChenRulong Yan
Published in: The Journal of organic chemistry (2017)
One-pot Cu-catalyzed tandem aerobic oxidative cyclization for the synthesis of quinolines from 2-vinylanilines/2-arylanilines and 2-methylquinolines via C(sp3)-H/C(sp2)-H bond functionalization has been developed. Dioxygen as an ideal oxidant has been employed for this transformation. The substrates bearing various functional groups perform well in this process and generate the desired products in moderate to good yields.
Keyphrases
  • high intensity
  • ionic liquid
  • metal organic framework
  • electron transfer