Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.

Rosa RademakersAlexandra M NicholsonYingxue RenShunsuke KogaHung Phuoc NguyenMieu BrooksWenhui QiaoZachary S QuicksallBillie MatchettRalph B PerkersonAishe KurtiMonica Castanedes-CaseyVirginia PhillipsAriston L LibreroCristhoper H Fernandez De CastroMatthew C BakerShanu F RoemerMelissa E MurrayYan AsmannJohn D FryerGuojun BuDennis W DicksonXiaolai Zhou

Published in: Brain pathology (Zurich, Switzerland) (2021)

TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.

Keyphrases

late onset
single cell
cell death
mouse model
traumatic brain injury
early onset
cell therapy
multiple sclerosis
stem cells
optical coherence tomography
high speed
risk assessment
climate change