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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.

Rosa RademakersAlexandra M NicholsonYingxue RenShunsuke KogaHung Phuoc NguyenMieu BrooksWenhui QiaoZachary S QuicksallBillie MatchettRalph B PerkersonAishe KurtiMonica Castanedes-CaseyVirginia PhillipsAriston L LibreroCristhoper H Fernandez De CastroMatthew C BakerShanu F RoemerMelissa E MurrayYan AsmannJohn D FryerGuojun BuDennis W DicksonXiaolai Zhou
Published in: Brain pathology (Zurich, Switzerland) (2021)
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss.
Keyphrases
  • late onset
  • single cell
  • cell death
  • mouse model
  • traumatic brain injury
  • early onset
  • cell therapy
  • multiple sclerosis
  • stem cells
  • optical coherence tomography
  • high speed
  • risk assessment
  • climate change