RhoA/ROCKs signaling is increased by treatment with TKI-258 and leads to increased apoptosis in SCC-4 oral squamous cell carcinoma cell line.

Anna Cecília Dias Maciel Carneiro Fernanda Bernadelli De Vito Helio Moraes-Souza Virgínia Oliveira Crema

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

Therapies with multi-target inhibitors, such as TKI-258, may be promising alternatives for the clinical treatment of oral squamous cell carcinoma.

Keyphrases

tyrosine kinase
oxidative stress
advanced non small cell lung cancer
endoplasmic reticulum stress
signaling pathway
replacement therapy
cell proliferation
epidermal growth factor receptor