Mediator of DNA damage checkpoint protein 1 (MDC1) as a prognostic marker for patients with oral squamous cell carcinoma.
Jigna Harshadbhai DaveHemangini Hasit VoraNandita Radhabinod GhoshTrupti Indravadan TrivediPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)
Thus, this study showed that MDC1 protein expression could be used as a prognostic marker in predicting relapse-free survival in patients with OSCC. OSCC patients expressing weak MDC1 protein could be benefited by adjuvant radiotherapy instead chemo-radiotherapy.
Keyphrases
- free survival
- dna damage
- early stage
- locally advanced
- end stage renal disease
- radiation therapy
- ejection fraction
- newly diagnosed
- chronic kidney disease
- radiation induced
- protein protein
- oxidative stress
- prognostic factors
- peritoneal dialysis
- dna repair
- squamous cell carcinoma
- cell cycle
- cell proliferation
- drug delivery
- rectal cancer
- cancer therapy
- combination therapy