Tau Mediates Synergistic Influence of Vascular Risk and Aβ on Cognitive Decline.
Wai-Ying Wendy YauZahra ShirzadiHyun-Sik YangAkpevweoghene P IkobaJennifer S RabinMichael J ProperziDylan R KirnAaron P SchultzDorene M RentzKeith A JohnsonReisa A SperlingJasmeer P ChhatwalPublished in: Annals of neurology (2022)
Vascular risks interact with subthreshold levels of Aβ to promote cognitive decline, partially by accelerating early neocortical tau accumulation. Our findings support vascular risk reduction, especially treating hypertension and obesity, to attenuate Aβ-related tau pathology and reduce late-life cognitive decline. ANN NEUROL 2022;92:745-755.