A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS.
Howard S OsterSimon CrouchAlexandra G SmithGe YuBander Abu ShrkiheShoham BaruchAlbert KolomanskyJonathan Ben-EzraShachar NaorPierre FenauxArgiris SymeonidisReinhard StauderJaroslav CermakGuillermo F SanzEva Hellström-LindbergLuca MalcovatiSaskia LangemeijerUlrich GermingMette Skov HolmKrzysztof MadryAgnes Guerci-BreslerDominic CulliganLaurence SanhesJuliet MillsIoannis KotsianidisCorine J van MarrewijkDavid BowenTheo de WitteMoshe MittelmanPublished in: Blood advances (2021)
We present a noninvasive Web-based app to help exclude or diagnose myelodysplastic syndrome (MDS), a bone marrow (BM) disorder with cytopenias and leukemic risk, diagnosed by BM examination. A sample of 502 MDS patients from the European MDS (EUMDS) registry (n > 2600) was combined with 502 controls (all BM proven). Gradient-boosted models (GBMs) were used to predict/exclude MDS using demographic, clinical, and laboratory variables. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity were used to evaluate the models, and performance was validated using 100 times fivefold cross-validation. Model stability was assessed by repeating its fit using different randomly chosen groups of 502 EUMDS cases. AUC was 0.96 (95% confidence interval, 0.95-0.97). MDS is predicted/excluded accurately in 86% of patients with unexplained anemia. A GBM score (range, 0-1) of less than 0.68 (GBM < 0.68) resulted in a negative predictive value of 0.94, that is, MDS was excluded. GBM ≥ 0.82 provided a positive predictive value of 0.88, that is, MDS. The diagnosis of the remaining patients (0.68 ≤ GBM < 0.82) is indeterminate. The discriminating variables: age, sex, hemoglobin, white blood cells, platelets, mean corpuscular volume, neutrophils, monocytes, glucose, and creatinine. A Web-based app was developed; physicians could use it to exclude or predict MDS noninvasively in most patients without a BM examination. Future work will add peripheral blood cytogenetics/genetics, EUMDS-based prospective validation, and prognostication.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ejection fraction
- bone marrow
- newly diagnosed
- peripheral blood
- oxidative stress
- primary care
- prognostic factors
- immune response
- mesenchymal stem cells
- blood pressure
- cell proliferation
- peritoneal dialysis
- patient reported
- signaling pathway
- uric acid
- cell death
- skeletal muscle
- current status