OTULIN's influence on neuroinflammation and pain modulation in trigeminal neuralgia.

Haiyang WangHeng WangWenhao ZhengDing WangChenglong SunJun Dong Wenhua YuQuan Du

Published in: CNS neuroscience & therapeutics (2024)

OTULIN is crucial in modulating TN, reducing neuropathic pain and neuroinflammation by activating the autophagy pathway and inhibiting the NLRP3 inflammasome.

Keyphrases

neuropathic pain
nlrp inflammasome
signaling pathway
spinal cord
lipopolysaccharide induced
spinal cord injury
lps induced
traumatic brain injury
cognitive impairment
cerebral ischemia
inflammatory response
cell death
oxidative stress
endoplasmic reticulum stress
chronic pain
pain management
blood brain barrier