Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents.
Rebeca González-PastorAhmad Mohammad AshshiAdel Galal El-ShemiIgor P DmitrievElena A KashentsevaZhi Hong LuS Peter GoedegebuureOsvaldo L PodhajcerDavid T CurielPublished in: Journal of ovarian research (2019)
Limits of widely employed murine xenograft models of ovarian cancer limit their utility for design and study of armed CRAd virotherapy agents. The ID8 model exhibited CRAd-induced oncolysis. This feature predicate its potential utility for the study of CRAd-based virotherapy agents.