Lymphocyte-to-monocyte ratio in predicting the calcific aortic valve stenosis in a Chinese case-control study.
Xiaochun MaHuibo MaYan YunShanghao ChenXiaofeng ZhangDiming ZhaoYanwu LiuHechen ShenChuanni WuJing ZhengTao ZhangZhenqiang XuLiangong SunHaizhou ZhangWenlong ZhangChengwei ZouZhengjun WangPublished in: Biomarkers in medicine (2020)
Aim: This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case-control study. Results: The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS. Conclusion: This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- ejection fraction
- peripheral blood
- end stage renal disease
- dendritic cells
- chronic kidney disease
- endothelial cells
- early onset
- coronary artery disease
- prognostic factors
- left ventricular
- patient reported
- data analysis