Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS.
Steven C KoetzierJamie van LangelaarKatelijn M BlokThierry P P van den BoschAnnet F Wierenga-WolfMarie-José MeliefKim PolTheodora A SiepmanGeorges M G M VerjansJoost J F M SmoldersErik LubbertsHelga E de VriesMarvin M van LuijnPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
This study reveals that GC resistance coincides with preferential CNS recruitment of pathogenic Th17.1 cells, which may hamper the long-term efficacy of GCs in early MS.