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Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS.

Steven C KoetzierJamie van LangelaarKatelijn M BlokThierry P P van den BoschAnnet F Wierenga-WolfMarie-José MeliefKim PolTheodora A SiepmanGeorges M G M VerjansJoost J F M SmoldersErik LubbertsHelga E de VriesMarvin M van Luijn
Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)
This study reveals that GC resistance coincides with preferential CNS recruitment of pathogenic Th17.1 cells, which may hamper the long-term efficacy of GCs in early MS.
Keyphrases
  • mass spectrometry
  • multiple sclerosis
  • ms ms
  • induced apoptosis
  • cell cycle arrest
  • white matter
  • gas chromatography
  • oxidative stress
  • endoplasmic reticulum stress
  • signaling pathway
  • pi k akt
  • simultaneous determination