Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.

Rabia BibiUmme SalmaKashif BashirTaous KhanAbdul Jabbar Shah

Published in: Arquivos brasileiros de cardiologia (2022)

S. guttatum has a vasodilatory effect through endothelial function preservation, muscarinic receptor-mediated NO release and Ca2+ movement inhibition, while atrial myocardial depressant effect can be linked to the muscarinic receptor. These findings provide pharmacological base for using S. guttatum extract as an antihypertensive medication.

Keyphrases

blood pressure
left ventricular
healthcare
atrial fibrillation
oxidative stress
emergency department
heart failure
left atrial
binding protein