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Dimethylacetamide-stabilized ruthenium nanoparticles for catalysing α-alkylations of amides with alcohols.

Honami IguchiNobuki KatayamaTakeyuki SuzukiTetsuaki FujiharaYuan JingTakashi ToyaoZen MaenoKen-Ichi ShimizuYasushi Obora
Published in: Chemical communications (Cambridge, England) (2022)
α-Alkylation reactions between amides and alcohols, with dimethylacetamide-stabilized Ru nanoparticles (NPs) as the catalyst, were investigated. The reactions proceeded with low catalyst loadings compared to metal complexes. Characterizations of the Ru NPs were performed by X-ray photoelectron spectroscopy, X-ray absorption fine structure spectroscopy, and various techniques. Control experiments revealed the reaction mechanisms, which proceeded via hydrogen autotransfer with alcohols.
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