The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
Alejandro ArtachoSandrine IsaacRenuka R NayakAlejandra Flor-DuroMargaret AlexanderImhoi KooJulia ManassonPhilip B SmithPamela RosenthalYamen HomsiPercio GulkoJavier PonsLeonor Puchades-CarrascoPeter IzmirlyAndrew PattersonSteven B AbramsonAntonio Pineda-LucenaPeter J TurnbaughCarles UbedaJose U ScherPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Taken together, these findings are the first step toward predicting lack of response to oral MTX in patients with new-onset RA and support the value of the gut microbiome as a possible prognostic tool and as a potential target in RA therapeutics.