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The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.

Alejandro ArtachoSandrine IsaacRenuka R NayakAlejandra Flor-DuroMargaret AlexanderImhoi KooJulia ManassonPhilip B SmithPamela RosenthalYamen HomsiPercio GulkoJavier PonsLeonor Puchades-CarrascoPeter IzmirlyAndrew PattersonSteven B AbramsonAntonio Pineda-LucenaPeter J TurnbaughCarles UbedaJose U Scher
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Taken together, these findings are the first step toward predicting lack of response to oral MTX in patients with new-onset RA and support the value of the gut microbiome as a possible prognostic tool and as a potential target in RA therapeutics.
Keyphrases
  • rheumatoid arthritis
  • disease activity
  • ankylosing spondylitis
  • interstitial lung disease
  • high dose
  • systemic lupus erythematosus
  • small molecule
  • human health
  • systemic sclerosis
  • risk assessment
  • climate change