Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions.

M MedranoM ContrerasT Caballero-VelázquezL MartínezJ A Bejarano-GarcíaR Calderón-RuizC B García-CalderónI V RosadoJosé Antonio Pérez-Simón

Published in: British journal of cancer (2024)

WIN-55 exerts an antileukemic effect through Parthanatos, leading to translocation of AIF to the nucleus and depletion of NAD+, which are reversed through PARP1 inhibition. It also induces metabolic disruptions. These effects are not observed in normal HSC.

Keyphrases

cell death
cell cycle arrest
dna damage
dna repair
induced apoptosis
oxidative stress
pi k akt
endoplasmic reticulum stress