Human Adipose-derived Stem Cells Upregulate IGF-1 and Alleviate Osteoarthritis in a Two-stage Rabbit Osteoarthritis Model.

Juan WangShibo SuChuanming DongQiang FanJishu SunSiqing LiangZuhuo QinChuqing MaJianfeng JinHongwen ZhuTong-Meng JiangJun Xu

Published in: Current stem cell research & therapy (2024)

Our data suggest that hADSC transplantation promotes articular cartilage healing in the double-damage rabbit osteoarthritis model, IGF-1 may play an essential role in the hADSC-based cartilage repair process. Transplantation of hADSCs may be suitable for clinical application in the treatment of osteoarthritis.

Keyphrases

rheumatoid arthritis
knee osteoarthritis
endothelial cells
oxidative stress
binding protein
electronic health record
stem cells
bone marrow