Superior Antitumor Efficacy of IFN-α2b-Incorporated Photo-Cross-Linked Hydrogels Combined with T Cell Transfer and Low-Dose Irradiation Against Gastric Cancer.

Qin LiuDinghu ZhangHanqing QianYanhong ChuYan YangJie ShaoQiuping XuBaorui Liu

Published in: International journal of nanomedicine (2020)

HPC hydrogels kept the activity of IFN-α2b and stably release of IFN-α2b to stimulate T cells for a long time. At the same time, low-dose radiation recruits T cells into tumors. This innovative integration mode of IFN-α2b-loaded hydrogels and radiotherapy offers a potent strategy to improve the therapeutic outcome of T cell therapy.

Keyphrases

low dose
cell therapy
drug delivery
dendritic cells
immune response
hyaluronic acid
wound healing
drug release
high dose
tissue engineering
radiation induced
stem cells
early stage
mesenchymal stem cells
cancer therapy
bone marrow
anti inflammatory
electron transfer