Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ.
Yu SunKate StensonMaradumane L MohanManveen K GuptaNicholas WannerKewal AsosinghSerpil ErzurumSathyamangla Venkata Naga PrasadPublished in: Circulation research (2023)
Agonist-independent activation of PI3Kγ underlies hypoxia sensing as its ablation leads to reduction in β1- and β2AR phosphorylation and amelioration of cardiac dysfunction.