AIM2-driven inflammasome activation in heart failure.
Zsófia OnódiMihály RuppertDániel KucseraAlex Ali SayourViktória E TóthGábor KoncsosJulianna NovákGábor B BrennerAndrás MakkosTamás BaranyaiZoltán GiriczAnikó GörbePrzemyslaw LeszekMariann GyöngyösiIván G HorváthRainer SchulzBela MerkelyPeter FerdinandyTamás RadovitsZoltan V VargaPublished in: Cardiovascular research (2022)
This is the first report showing that AIM2 and NLRC4 inflammasome activation contribute to chronic inflammation in HF and that probenecid alleviates chronic HF by reducing inflammasome activation. The present translational study suggests the possibility of repositioning probenecid for HF indications.