Benzene and 2-ethyl-phthalate induce proliferation in normal rat pituitary cells.
Laura TapellaAntonella SestaMaria Francesca CassarinoValentina ZuninoMaria Graziella CatalanoFrancesca Pecori GiraldiPublished in: Pituitary (2018)
Our findings indicate that benzene and 2-ethyl-phthalate activate AhR/AIP expression and stimulate proliferation in normal rat pituitary cells. This study is the first demonstration that pollutants can induce normal pituitary cells to proliferate and provides a link between epidemiological and genomic findings in pituitary tumors.