Bone marrow mesenchymal stem cell-derived exosomal miR-221-3p promotes angiogenesis and wound healing in diabetes via the downregulation of forkhead box P1.
Zhi-Yang QiuWei-Cheng XuZun-Hong LiangPublished in: Diabetic medicine : a journal of the British Diabetic Association (2024)
Exosomal miR-221-3p isolated from BMSCs promoted angiogenesis in diabetic wounds through the mediation of the FOXP1/SPRY1 axis. Furthermore, the findings of this study can provide new insights into probing strategies against diabetes.
Keyphrases
- wound healing
- bone marrow
- type diabetes
- mesenchymal stem cells
- cardiovascular disease
- transcription factor
- glycemic control
- endothelial cells
- regulatory t cells
- vascular endothelial growth factor
- cell proliferation
- signaling pathway
- umbilical cord
- single molecule
- stem cells
- metabolic syndrome
- molecular dynamics simulations
- depressive symptoms
- insulin resistance
- dendritic cells