Effects of Translumbosacral Neuromodulation Therapy on Gut and Brain Interactions and Anorectal Neuropathy in Fecal Incontinence: A Randomized Study.

Satish S C RaoYun YanXuelian XiangAmol SharmaDeepak AyyalaShaheen Hamdy

Published in: Neuromodulation : journal of the International Neuromodulation Society (2021)

TNT significantly improves afferent ano-cortical signaling, efferent lumbo-anal and sacro-anal neuropathy and anorectal sensorimotor function. These neurobiologic effects were most prominent with 1 Hz frequency. TNT improves FI by modifying the underlying pathophysiology possibly through neuromodulation.

Keyphrases

high grade
resting state
functional connectivity
white matter
stem cells
mesenchymal stem cells