The proportion of endometrial tumours associated with Lynch syndrome (PETALS): A prospective cross-sectional study.
Neil A J RyanRaymond F McMahonSimon TobiTristan M SnowsillShona EsquibelAndrew J WallaceSancha BunstoneNaomi BowersIoana E MosneagSarah J KitsonHelena O'FlynnNeal C RamchanderVanitha N SivalingamIan M FraylingJames BoltonRhona J McVeyDafydd Gareth EvansEmma J CrosbiePublished in: PLoS medicine (2020)
In this study, we observed that age, family history, and histology are imprecise clinical correlates of LS-EC. IHC outperformed MSI for tumour triage and reliably identified both germline and somatic MMR mutations. The 3.2% proportion of LS-EC is similar to colorectal cancer, supporting unselected screening of EC for LS.