Pew2: Open-Source Imaging Software for Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.
Thomas E LockwoodMika T WesterhausenPhilip A DoblePublished in: Analytical chemistry (2021)
Open-sourced software is a key component of the mass spectrometry imaging field, where transparency in data processing is vital. Imaging of trace elements and immunohistochemically labeled biomolecules in tissue sections is typically performed using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). However, efficient and facile processing of images is hampered by a lack of verifiable and user-friendly software that supports multiple LA-ICP-MS platforms. In this technical note, we introduce Pew2, a LA-ICP-MS specific and feature-rich open-source image processing software that is compatible with common ICP-MS vendors. Pew2 is designed to be fast and easy to use and adheres to modern visualization philosophies to maximize productivity and to minimize data interpretation errors and image anomalies.
Keyphrases
- mass spectrometry
- high resolution
- capillary electrophoresis
- high performance liquid chromatography
- liquid chromatography
- deep learning
- data analysis
- gas chromatography
- multiple sclerosis
- electronic health record
- climate change
- ms ms
- big data
- machine learning
- high speed
- fluorescence imaging
- radiofrequency ablation
- adverse drug
- quantum dots
- patient safety