Preconditioning of Human Decidua Basalis Mesenchymal Stem/Stromal Cells with Glucose Increased Their Engraftment and Anti-diabetic Properties.
Yasser S BasmaeilManar Al RashidTanvir KhatlaniManal AlShabibiEman BahattabMeshan L AbdullahFawaz AbomarayBill KalionisSafia MassoudiMohammad AbumareePublished in: Tissue engineering and regenerative medicine (2020)
These data show the potentially beneficial effects of glucose on DBMSC functions. Preconditioning of DBMSCs with glucose may therefore be a rational strategy for increasing their therapeutic potential by enhancing their engraftment efficiency. In addition, glucose may program DBMSCs into insulin producing cells with ability to counteract inflammation and infection associated with diabetes. However, future in vitro and in vivo studies are essential to investigate the findings of this study further.
Keyphrases
- type diabetes
- blood glucose
- glycemic control
- endothelial cells
- induced apoptosis
- oxidative stress
- stem cells
- ischemia reperfusion injury
- cardiovascular disease
- blood pressure
- quality improvement
- electronic health record
- adipose tissue
- big data
- machine learning
- cell death
- induced pluripotent stem cells
- blood brain barrier
- artificial intelligence