A descriptive study on isoniazid resistance-associated mutations, clustering and treatment outcomes of drug-resistant tuberculosis in a high burden country.
Juliana Maira Watanabe PinhataLucilaine FerrazoliFlávia de Freitas MendesMaria Gisele GonçalvesMichelle Christiane da Silva RabelloKelen Teixeira GhisiVera SimonsenRoberta Figueiredo CavalinAna Angélica Bulcão Portela LindosoRosângela Siqueira de OliveiraPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2023)
We found that katG and inhA mutations were not equally distributed between isoniazid-monoresistant and MDR isolates. In our population, clustering was higher for isolates with inhA mutations. Finally, unfavourable TB outcomes were associated with specific factors.