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Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice.

A K OestreichS M CarletonX YaoB A GentryC E RawM BrownF M PfeifferY WangCharlotte L Phillips
Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2015)
Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and physiochemical properties.
Keyphrases
  • bone mineral density
  • bone regeneration
  • soft tissue
  • bone loss
  • high fat diet induced
  • postmenopausal women
  • mouse model
  • replacement therapy
  • insulin resistance
  • smoking cessation